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A sperm-specific PLC (phospholipase C) isoform, PLCζ, is widely considered to be the physiological stimulus that triggers these intracellular Ca2+ oscillations at fertilization [ 3– 7].
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Calcium is the physiological stimulus that activates calcium-activated chloride channels (CaCCs).
But what are the physiological stimuli regulating the progression of one dHSC into an aHSC?
Once the capacitation was completely achieved and the physiological stimulus (ZP proteins) was detected, the AR takes place and the ZP-induced calcium peak causes the fast depolymerisation of actin structure.
In addition, XBP-1s, a product of the master gene responsible for B cell differentiation, was recently suggested to be one of the physiological stimuli that trigger the lytic switch of EBV and KSHV in latently infected B cells [7], [8].
A positive control was included by adding the physiological stimulus progesterone, which causes increased Ca2+ levels and triggers AR, to ensure that all samples were responding normally.
Nociception is the physiological detection of stimuli that are potentially damaging to tissue [1] [2].
It is also noticed that the physiological stimuli are usually dynamic rather than static, which highly depends on the magnitude, frequency, and duration of mechanical forces.
Studies show that the physiological stimulus of enteral nutrition is crucial to maintain gastrointestinal functions such as barrier, immunological, and resorptive function.
Nociception is the physiological detection of noxious stimuli.
It is tempting to speculate over the mechanism by which the V1-ATPase is assembled, however further analysis is required to identify the physiological stimuli for such an event.
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