Sentence examples for be the physiological importance from inspiring English sources
What might be the physiological importance of mitonuclear coevolution in complex I? Remarkably, genetic variants in close linkage with NDUFC2, a subunit which physically interacts with the mtDNA-encoded complex I subunit ND4, were recently associated with decreased glucose-stimulated insulin secretion (Olsson et al. 2011).
Together with our previous results, this suggests that WscA and WscB participate in the tolerance to hypo-osmotic stress in A. nidulans, although their precise roles are unknown, as is the physiological importance of transient MpkA-RlmA signaling in hypo-osmotic stress tolerance.
There is evidence for the physiological importance of modest changes in SOX9 activity from mouse genetic studies, which show that the level of SOX9 expression is critically important to the chondrocyte phenotype during development, as either the knock-out or the knock-in of a single SOX9 allele has a severe effect on chondrocyte differentiation and on cartilage development (2, 6).
Pharmacological modulation of the UPR is challenging considering the physiological importance of the pathway in various organs.
Further work will be necessary to define the physiological importance of the interaction between RAB7A and peripherin in vivo, and its relevance to peripheral neurons expressing CMT2B-causing RAB7A mutants.
It is important to address the physiological importance of hyperphosphorylation of RPA2 in response to DNA damage in human (and potentially many higher eukaryotic) cells.
Further investigations are required to define the physiological importance of these Akt phosphorylation sites and feedback regulation between of Akt-MST in knock-in mouse model.
The GNN also is useful to assess the physiological importance of in vitro promiscuity.
Further studies are required to define the physiological importance of relaxin-3 in the regulation of reproduction.
Despite the elucidation of the molecular mechanism of EE motility, there was little known about the physiological importance of this transport process.
This result suggests that it is obscure to infer the physiological importance of these single-point mutations only from their conservativeness in primary structure.
