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Furthermore, in contrast to Braak et al.'s thinking, the proposal was made that αsyn itself may be the pathogenic factor underlying the spread of the disease.
Animal fat, including that found in whole milk and high-fat dairy products, was thought to be the pathogenic factor with little consideration of the composition of milk fat, which has the potential opposite effects of various fatty acids (saturated fatty acids, trans fatty acids, and conjugated linoleic acid) (2).
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In particular, RANKL is the pathogenic factor that cause bone and cartilage destruction in arthritis.
Shiga toxin produced by Escherichia coli is the pathogenic factor in STEC-HUS [ 64– 64].
A complex interplay of genetic and probably environmental factors could be the pathogenic trigger for MN.
Much interest has been focused on the pathogenic factor CagA, which is transported via the T4SS into the host cytoplasm where it activates signal transduction pathways leading to cancer-associated processes [ 5].
The study is concerned with the question, whether several changes in atmosphere state might be the reasonable pathogenic factor to excite deteriorations in person' well-being.
In conclusion, our data show that HCV infection could be the main pathogenic factor of lichen planus in Japanese patients.
The frequent occurrence of scoliosis in patients with CORE Myopathies, supports the thesis that the change in the paravertebral muscle fiber must be the underlying pathogenic factor in scoliosis and may help us understand the onset and progression of curves in patients previously diagnosed with idiopathic scoliosis.
18 Therefore, overexpression of Wnt proteins may be one of the pathogenic factors to be implicated in aging, and klotho is a secreted Wnt antagonist.
Although the upregulation in stress response may have a role in disease progression, it is unlikely that this is the major pathogenic factor responsible for the development of locomotor deficits in tgMT mice.
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