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A preliminary dose response study performed in weanling rats determined 2000 μg/kg/day to be the optimal dose of 16α-OHE1 for studying estrogenic effect on bone.
Zymosan at 40 µg/ml and Curdlan at 20 µg/ml were found to be the optimal dose for the present study (Figure S1).
Therefore, as observed for MDDC maturation and CD8+ T cell proliferation, 0.3 PFU/MDDC was found to be the optimal dose for cytokine secretion (Figure 5).
In a dose-response analysis of CD86 expression and MVA-B dose, at 16 h post-infection, in the absence of maturation cocktail, 0.3 PFU/MDDC was found to be the optimal dose at which CD86 expression assessed as MFI was maximal (Figure 2B).
The dose of 0.3 PFU/MDDC was found to be the optimal one for MDDC viability, maturation and high levels of Gag-antigen expression, and, accordingly, it was also found to be the optimal dose for HIV-1-specific CD8+ T cell responses.
These data imply that 0.4 0.6 units/kg may be the optimal dose range.
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However, Cmax or the maximally tolerated doses of these HDACIs may not be the optimal doses for combination therapy with cytarabine.
According to Katz, there are many unanswered questions about chocolate: What is the optimal dose of dark chocolate?
The results illustrated that 25 μg was the optimal dose and intramuscular injection was the most effective route to induce protective immunity.
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response.
This study suggests that 250 μg is the optimal dose of intrathecal morphine to provide significant postoperative analgesia without delaying tracheal extubation.
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