Sentence examples for be the maximum dose from inspiring English sources
In the present study, dref was chosen to be the maximum dose Dmax.
Given that bone marrow suppression is a proangiogenic stimulus, we propose that the MetD should be the maximum dose that can be delivered in a metronomic schedule without detectable bone marrow perturbation.
The supratherapeutic dose used in this study was assessed and found to be safe in a previous phase I cardiac safety study, and is likely to be the maximum dose tolerated in the majority of healthy volunteers (unpublished data).
Owing to the solubility of SR4554, which limited the maximum dose that could be administered in 1 l of 0.9% saline to 5.4 g, it was decided that 2600 mg m−2 would be the maximum dose to be explored, that is, close to the maximal deliverable dose in a 1 l volume for a patient with a body surface area of 2.0 m.
This particular dose was chosen because of the efficacy and comparative effectiveness of the inhibition of mTOR signaling by rapamycin as shown in previous studies, furthermore, in preparatory undertakings for this study, this was found to be the maximum dose without seeing significant body weight loss.
In a Phase I study in healthy volunteers, a landiolol hydrochloride dose of 0.5 mg/kg was found to be the maximum dose that did not cause any abnormalities or variations in signs/symptoms, ECG findings, physiological tests, or laboratory tests, and was well tolerated [ 26].
The VAS score was 10 and the dose of BTX-A was 170 U (which was the maximum dose we used in all TN patients, she received an additional dose 10 days after the first injection).
A dose of 5 ng/ml of skTRAIL was chosen for subsequent experiments given that this was the maximum dose of skTRAIL that had only limited impact on cell viability.
Both were found to be safe up to 2000 mg/kg which was the maximum dose tested.
Thus, 2.5 × 10 GC/eye which is the high 1 1 dose (10 10) is the maximum dose which we can administer to the murine eye.
Our dose of piroxicam is the maximum dose possible without yielding significant effects on cell division and viability as demonstrated by Chang et al. [ 32].
