Sentence examples for be the main effector from inspiring English sources

Whereas CTLs are traditionally thought to be the main effector cells that eliminate HCV-infected cells [5], it is clear that HCV-specific CD4+ T cells also play a critical role.

CD8+ cytotoxic lymphocytes (CTLs) are known to be the main effector cell in viral infection [ 6].

In these stages, YAP may be the main effector, providing a potential therapeutic target of the AKI CKD transition.

Because of its limited binding capacity for calcium, S100A4 might not be the main effector of calcium increase in cell upon induction by CCN3.

Although epidemiologic studies propose that PM mass is the metric most strongly associated with adverse events, our studies suggest that composition strongly affects potency and is likely to be the main effector of outcome.

Antibody-dependent cellular cytotoxicity is suggested to be the main effector mechanism of WX-G250 (Surfus et al, 1996) and is mediated by the interaction between the Fc region of an antibody bound to a tumour cell and the Fc γ receptors on immune effector cells, such as neutrophils, macrophages and NK cells (Clynes et al, 2000).

Throughout the chapter, attention is drawn to the fact that, while the majority of ADCC studies have been based on research using peripheral blood mononuclear cells in which NK cells have been assumed to be the main effectors, questions remain unanswered about ADCC mediated by non-NK cell populations in peripheral blood and in mucosal compartments.

Human NK cells appear to be the main effectors with combined lenalidomide and ch14.18 treatment because tumor growth was less and survival was longer for mice receiving PBMC versus NK-depleted PBMC.

On the other hand, MSD liver sections exhibited a high concentration of TUNEL-positive cells per area analyzed, thus suggesting that mitochondria might be the main effectors of cell death in this tissue.

Caspase 3 is the main effector caspase that is involved in both external and internal apoptosis pathway and it is the most abundant caspase in the brain [22].

CD8+ T cells are the main effector cells responsible for viral clearance as well as disease pathogenesis during HBV infection (Thimme et al., 2003; Harari et al., 2006; Ouyang et al., 2013).