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The proposed work will be the largest published cohort study exploring determinants of responsiveness to oral corticosteroids in children treated according to evidence-based acute asthma guidelines.
It will be the largest published single-centre study cohort of patients with necrotising soft tissue infections (NSTI) exploring biomarkers during admission.
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As far as we are aware, this is the largest published listing of this type and presents a detailed assessment of the major part of the human molecular target landscape that has been, or is, under active investigation [41].
Major strengths of the present study are that all pregnant women in a certain period were invited prospectively, thereby avoiding selection bias, and that the number of women answering the questionnaires (from n = 2,126 for Q1 to n = 1,273 for Q3) and migraineurs volunteering to fill in calendars (n = 208) are the largest published so far for this type of study.
Nevertheless, our ILC group is the largest published to date.
At the time of writing, this is the largest published RCT on this topic.
To our knowledge, this is the largest published study on CTCs with mature outcome data.
The PATH trial is the largest published trial of antioxidant therapy conducted to date in patients undergoing maintenance HD.
This is the largest published trial to date to study the mode of solute clearance in AKI.
To our knowledge this is the largest published report on ILC that comprehensively evaluates biologic characteristics and clinical outcomes.
Their study is the largest published so far and raises issues of interest to both ICU physicians and nephrologists.
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CEO of Professional Science Editing for Scientists @ prosciediting.com