If the loss of amyloid formation is the key defect in Als5pV326N, then chemical inhibition of amyloid formation should show similar effects, and the residual activity of the Als5pV326N protein should be resistant to the inhibitors.
Moreover, recovery from mitosis-inhibition by monastrol revealed a high incidence of merotelic attachment that was nearly identical with condensin depletion, Aurora B inactivation, or both, indicating that the Aurora B dysfunction is the key defect leading to chromosome missegregation in condensin-depleted cells.
This effect was attenuated when adjusted for Matsuda ISI but abolished after adjustments with DI30 suggesting insulin secretion is the key defect leading to type 2 diabetes after GDM pregnancy.
As the primary cause of software defects, human error can be the key to understanding and preventing software defects.
Although the dolphin seemed otherwise healthy, that probable birth defect could be the key to understanding its attachment to the sperm whale group.
When aberrant RLR signaling is activated, the key defects may be cell autonomous.
The proposed risk management framework enables an product development to be focused on the key defect activities in which the most serious defect risk exists and provides a more effective way to assess, identify defect risk along the product development cycle.
However, we also see loss of this mutant from the nucleus and so whether the key defect is loss of localization to centrosomes and cilia, or rather the nucleus, is not clear.
Impulses occurring at specific period is the key characteristic of corresponding defect.
Companies use it to raise quality and efficiency by spotting and removing causes of defects, and here measuring is the key, whether it is measuring defects, waste or results.
