Sentence examples for be the initial event from inspiring English sources
LOH in B2M might be the initial event toward complete loss of the B2M gene, followed by MHC class I and antigen presentation loss.
However, PIK3CA activation might not be the initial event in OSE transformation, and may require cooperation with other oncogenic events such as K-ras mutation to maintain transformed OSE growth.
With the likely assumption that the effects are due to CEA and CEACAM6, clustering of these molecules as their concentration increases by self-binding of their adhesive external domains [18] is suggested to be the initial event leading to the changes in cellular state observed here.
Endothelial cell proliferation may thus be the initial event in RA.
In the pathogenesis of Sjögren's syndrome, the activation of salivary gland epithelial cells appears to be the initial event.
CDK4 overexpression could be the initial event leading to a reactive overexpression of p16INK4A and to a break in the G1-S transition through pRb phosphorylation [ 49].
Although p53 and H- ras mutations are common they may not be the initial events in skin carcinogenesis.
Endothelial cell (EC) injury and proliferative dysfunction are considered to be the initial events in the development of atherosclerosis, postangioplasty restenosis, plaque erosion, and thromboembolism, which are contributors to macro-vascular complications [ 5].
The aforementioned results raise the possibility that alterations in mitochondrial energy metabolism play a role in the modulation of autophagy and, therefore, multiple defects in mitochondria-dependent metabolism might be the initial events in sPD-related autophagy pathology.
We propose that loss of homeostasis is the initial event that precipitates inflammation and that such inflammatory response includes not only the adaptive response, but also an intense innate immune/bystander response.
