In LOAD, accumulation of toxic Aβ and p-tau may not be the initial cause of neural degeneration and may instead be consequences of other causative factors5,6.
Maybe the initial causative factor is different.
Re-infection was defined as the growth of the initial causative bacterial strains, taken from the same infection site after ≥ 48 h of stopping antibiotics, in addition to clinical signs or symptoms of infection.
What was the initial connection?
In the other 5 investigations, B. anthracis was not found to be the causative organism, despite initial suspicion.
Our results show that H2O2 induced over-activation of the canonical WNT pathway, indicating: (1) that free radicals in oxidative stress and subsequent lipid peroxidation are initial causative factors for activation of the canonical WNT pathway; and (2) the possible involvement of HNE in oxidative stress-mediated signalling.
These observations demonstrate that gene activation can occur upon ablation of promoter hypermethylation even when the hypermethylation was not the initial and causative silencing event.
Using traditional approaches of human genetics, such as positional cloning, meiotic mapping, physical mapping and candidate-gene sequencing [ 15], PKD1 in PKD [ 16] and NPHP1 in NPHP [ 17] were identified as initial causative genes of ciliopathies in the late 1990s.
However, there is increasing evidence that in LOAD the accumulation of these toxic molecules may not be the sole or initial cause of the disease and may instead be consequences of other causative factors4,5,6,9,10.
"I wasn't thinking this would be the causative molecule until I talked to Vikas," he said.
