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One possible reason for this increased rate of side effects might be the high dose of imatinib (800 mg d−1) used in this study.
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The reason for this could be the higher dose of IPSTK used in this study.
Bortezomib at 0.2 0.3 μg per embryo was found to be the highest dose that did not cause significant BM toxicity.
One possible reason for this is the high dose of radiation, which completely obliterated the hypoxia-induced angiogenic signal (though HIF-1α was increased).
An additional concern, with the risk of breast cancer in this age group, is the high doses of DHEA supplementation used.
The MTD is the highest dose that is associated with no pre-specified infusion associated events or unexpected severe adverse attributed to the study product.
After an overnight fast, over a period of 1 hour, 4.8 g phenylacetate was ingested, which is the highest dose used to probe Krebs cycle metabolism.
Of note, 2×106 PFU is the highest dose possible for mucosal vaccination based on the concentration of our viral stocks.
All drug doses were determined empirically, i.e. it was the highest dose possible that did not affect locomotor behavior or induce catalepsy, except ketamine (see below).
The concentration of compound used was the highest dose possible in 1536-well format, since DMSO concentrations above 1% resulted in cellular toxicity (data not shown).
The maximum tolerated dose was the highest dose which did not cause escalation to cease.
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