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If one or more further DLT events are seen the recommended dose for phase II will be the first dose level.
The MTD was defined to be the first dose that caused a DLT (grade 3/4 toxicity – see prior section) in one-third or more of the patients treated.
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At the end of the trial, the MTD was selected to be the fifth dose level, that is, 5 mg m−2 day−1, with estimated DLT probability of 36.1%95%5% credibility interval: 15.8 58.6%).
Furthermore, ours is the first dose study in which correction for percentage predilution was performed in the calculation of CRRT dose, resulting in a more accurate estimate.
We assumed that vaccinations received before 12 months of age were the first dose of measles vaccine, and vaccinations after 12 months were booster vaccinations.
The two vaccines that have lower probability of being delivered are the first doses of polio (OPV1), and pertussis, tetanus, and diphtheria (DTP1).
By contrast, this is the first dose-ranging study that demonstrates the efficacy of an antihistamine at the end of the dosing interval.
The present study is the first dose-response meta-analysis on the association between fish consumption and risk of developing RA.
This is the first dose-finding study evaluating the combination of docetaxel/bevacizumab therapy in older patients with non-squamous NSCLC.
In conclusion, INTRAGO is the first dose-finding study on low-kV-IORT for newly diagnosed GBM in the temozolomide era with optimized geometry adaptation.
This was the first dose-finding study of an erythropoietic agent in patients with anaemia of cancer not concurrently being treated with chemotherapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com