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Although not conclusive, our results indicate that differential larval nourishment may be the environmental trigger and that differential activity of the physiological machinery that regulates diapause-derived circuits may be the consequent response.
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Another potential consideration is the environmental triggers and/or colony differences related to microbiota colonization in each holding facility.
In particular, both genetic and environmental factors interact in diseases, and the genetic architecture for two diseases could be similar, but the environmental triggers could be different, leading to low co-occurrence.
In the patient described above, the environmental trigger was hypothesized to be Shiga toxin-mediated damage of the endothelial cell.
Also, due to a huge lag time between the time of exposure and the onset of disease, sometimes it is difficult to identify the environmental trigger itself.
101 Furthermore, assessing the validity of epigenetic inheritance, in other words the transmission of epigenetic regulatory features acquired as an adaptive response to an environmental signal affecting one generation to subsequent generation(s) that has not been exposed directly to the environmental "trigger(s)", will have major implications in forecasting the societal burden of chronic disease.
Our data suggest that Arctic zooplankton are able to detect and respond to subtle changes in irradiance, and imply that light is the key environmental trigger to maintain distinct DVM cycles during the polar night.
"We think the Epstein-Barr virus is the main environmental trigger," Dr. Harley said in a telephone interview.
The Panel rightly points out that we are devoting more resources to understanding cancer genetics and the molecular pathways of cancer than we are to understanding the environmental triggers of cancer.
"They are more sensitive to the environmental triggers to cancer.
It has also been shown that treatment with IFNα rapidly downregulates expression of BLK and, moreover, its expression is negatively regulated by infection with Epstein-Barr virus, which has been suggested as one of the environmental triggers for autoimmune diseases [ 170].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com