Because migration and invasion are the early steps of metastatic progression, the novel markers that we identified here might become valuable prognostic tools or therapeutic targets in breast cancer.
Mevalonic acid is a precursor to the mevalonate pathway, which is the early step of juvenile hormone (JH) synthesis in insects [ 48].
The first stars, and the galaxies that harbored them, were the earliest steps in the process of cosmic evolution that led to the modern universe.
The mouse studies are the earliest steps to finding a potential therapy to help humans who develop the irreversible complication, called hyperthermia, after an Ecstasy overdose.
In particular, it is the earliest steps of fracture healing that seem to be blocked, in the absence of BMP-2, and MSCs at the repair site do not differentiate, leading to a failed healing response.
"This fossil was the earliest step toward humans," said co-discoverer Russell Ciochon, now chair of anthropology at the University of Iowa, Iowa City.
HSCs activation is the earliest step in hepatic fibrogenesis, collagen deposition, and progressive fibrosis leading to cirrhosis.
Reconstitution and maintenance of an intact endothelial layer is a crucial homoeostatic function of the cardiovascular system because endothelial damage is the earliest step in the atherogenetic process [ 5].
Along this line, it is tempting to speculate that clone A is reproducing the early steps which led to the speciation of M. tuberculosis.
Larson applauds the work, as it is revealing the early steps of domestication.
