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Disruption of plaques is now considered to be the common pathophysiologic substrate of an ACS.
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Furthermore, oxidative stress and hypoxia which are the common pathophysiologic contributors in AD [32] have been shown to modulate DNA methylation and histone methylation [33].
While the exact mechanisms by which a diabetic state leads to low lung function and whether a low lung function is predictive of development of diabetes remains to be elucidated [ 10], obesity, chronic systemic inflammation, and insulin resistance have been suggested as the common pathophysiologic determinants [ 15– 17].
Whether this association might in part be explained by common pathophysiologic pathways currently is unknown (e.g., the GIGYF2 gene involved in both IGF and insulin-signaling pathways recently has been identified as the PARK11 gene, but current literature does not provide strong support for its role in Parkinson's disease).
The metabolic syndrome also called (insulin resistance syndrome and X syndrome) is a common pathophysiologic condition with implications for the development of many chronic diseases.
Phagocyte-rich lymphatic tissue is a common pathophysiologic niche for pathogenic Yersiniae, which carry Ybt biosynthetic genes.
If a decrease in aqueous flow accompanies diabetic retinopathy, and if these changes are related by common pathophysiologic mechanisms, it is hypothesized that patients with evidence of retinopathy will have decreased aqueous flow that could impact IOP.
Cardiac myocyte dysfunction and fibrosis is believed to be the predominant pathophysiologic mechanism.
A dyshomeostasis of macro- and micronutrients, including vitamin D and oxidative stress, are common pathophysiologic features in patients with congestive heart failure (CHF).
Acute and chronic renal damage are also very common pathophysiologic disturbances caused by CCl4.
Renal hypoperfusion seems to be the most important pathophysiologic mechanism.
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