Sentence examples for be the cell of from inspiring English sources
The Schwann cell was discovered to be the cell of origin for neurofibromas, but understanding of a more complicated interplay of multiple cell types in tumorigenesis, specifically recruited heterogeneous cell types such as mast cells and fibroblasts, has important implications for surgical therapy of these tumors.
However, in the case of biliary cirrhosis specific stainings suggested HPCs to be the cell of origin to repopulate and regenerate injured bile ducts [ 101].
26 In the small intestine, LGR5+ve cells at the bottom of crypts can be the cell of origin for all cell types in the epithelium.
The Lgr5-expressing stem cell is a critical contributor to tissue maintenance, and may also be the cell of origin in gastrointestinal cancers [ 8, 9].
Fetal germ cells are also believed to be the cell of origin for testicular germ cell cancers in young men (Rajpert-De Meyts 2006).
Patients with BRCA1 mutations are commonly diagnosed with basal-like tumors [ 23]; earlier work suggested that luminal progenitors appear to be the cell of origin of these tumors and are regulated by c-kit [ 24].
Luminal cells are traditionally believed to be the cell-of-origin for human PCa due to the predominantly luminal-like phenotype of the disease.
We sporadically (below 0.5%) found K14+ cells with recombined Notch1 loci hypothesizing that these cells could be the cell-of-origin for papilloma development (Fig. 3B).
For instance, in a normal intestine, only the stem cell population is reported to be the cell-of-origin for adenoma formation [ 11].
Potentially, we also aim to integrate the data of the available cell types, stem cells among others, from normal lungs to find which normal cell type tends to be the cell-of-origin of which of the SqCC subtypes.
