Sentence examples for be the causative variant from inspiring English sources

AD was in line with T1D, suggesting that the rs12708716 rs12917716 risk haplotypes (III and IV) pointed to an untyped SNP, in strong LD with both, to be the causative variant.

Rs7528684 is considered to be the causative variant of the FCRL3 region to which NFκB binds and activates B cells to produce antibody by augmenting BCR-mediating signals [ 38].

Genotyping was performed for the XM_001491331 c.2032G > A variant in the PLOD1 gene, which is supposed to be the causative variant for Warmblood Fragile Foal Syndrome type 1 (WFFS) according to the patent application [ 39] (primers and PCR conditions available from Laboklin, Bad Kissingen, Germany upon request).

Based on this and other recent studies it is likely that SNP9, rs10993994, is the causative variant in the association of MSMB with PrCa risk.

57K being the causative variant for AGA might be regarded as less likely as this allele is fixed in East Asia whereby the prevalence of AGA is lower in this population compared to Europeans.

Another explanation could be that the causative variants differ between populations.

First among these is that the majority of SNPs that have been identified through this approach are rarely the causative variants (9).

Strong allelic imbalance in heterozygotes implies that the observed inclusion of the cassette exon is regulated in cis, and that the identified cis-sQTL most likely is the causative regulatory variant.

This provides further evidence that rs10993994 (SNP9) is likely to be the strongest causative variant.

In order to decipher which of these risk alleles might be the true causative variant (or in high LD with it) and thus may be suitable for testing in non-European populations, we studied the haplotype diversity across the different geographic regions for eight highly correlated CHD-associated SNPs (r2 > 0.9 in CEU HapMap population; Table 2).

However, DAE-based approaches can point out the presence of a regulatory causative variant only if the subjects are heterozygous for the causative variant (and of course for the coding SNP serving as marker).