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Special regulatory designations allow drugs to be approved at earlier stages based on less rigorous clinical testing; for example, one review showed drugs with orphan designations or granted accelerated approval are also more likely than drugs without these designations to be tested in single arm studies without placebo or active comparators.
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Ideally, mediators identified based on common sense and focus groups may be tested in single-case experiments, prior to their investigations in randomized clinical trials.
The scenarios were tested in single dose and steady state studies.
The effectiveness of EDTA was tested in single- and two-phase flow experiments.
The best performing cathode is tested in single cell setup using a standard carbon supported Pt0.4Ru0.2 based anode.
In the first trial, carp and tilapia were tested in single culture and in mixed culture with supplementary feeding at 2× maintenance level.
These materials were tested in single edge notch tensile tests as a function of test speed over a test speed range of 10−4 10 m s−1(2.85×10−3–2.85×102 s−1).
The catalysts were tested in single direct ethanol fuel cells and the result obtained with PtRu and PtSn showed that the mesh based electrodes show competitive performance in comparison to the conventional carbon based anodes.
Eight classes from class I to IV BCS drugs (with high or low intrinsic clearance) in two variability scenarios (high low) and in six drug products of decreasing quality were simulated in non-linear conditions to complete a total of 96 scenarios that were tested in single dose and steady state studies and compared with the previous results obtained under linear conditions.
The prepared catalysts were tested in Single Chamber Microbial Fuel Cell (SCMFC) with Escherichia coli of type DH5-α as bacterium.
The measurements were tested in single and dual-task conditions, with and without vision.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com