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The long-term outcome of the procedure remains unclear, however, and its effectiveness has yet to be tested in randomised clinical trials.
The increasing amount of evidence about the linkage between toxicity and efficacy needs to be tested in randomised trials.
The actual increase in performance of preventive activities that may result from this new intervention needs to be tested in randomised controlled trials.
Future developments in surgical techniques to treat these fractures should be tested in randomised controlled trials before they are widely used.
The purpose was to define doses that could be tested in randomised trials comparing combinations of irinotecan and 5-FU, and oxaliplatin and 5-FU.
These potential benefits for muscle function or other outcomes of selumetinib and potentially of other MEK inhibitors remain to be tested in randomised trials.
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The effectiveness of the nine-session group programme TRAMPOLINE for children from substance-affected families will be tested in a multicentre randomised controlled trial.
Our study suggested the possible mechanisms of resistance to combined therapy in those patients with a progressive disease to be tested in ongoing phase III randomised studies.
Based on these data, this approach should be tested in a larger randomise trial to determine the clinical impact of tumour down staging before surgery and the long-term impact of pathological tumour regression.
Two versions of the intervention will be tested in a three-group cluster randomised controlled trial.
Continuous hyperfractionated accelerated radiation therapy (CHART), which reduces overall treatment from 6-7 weeks to 12 days and gives 36 small fractions, has now been tested in multicentre randomised controlled clinical trials.
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