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Torgersen and coworkers brought us some novel thresholds, however, which should be tested in multicenter trials.
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Current JAK2 inhibitor based combination therapy approaches are supported by preclinical investigation and are currently being tested in multicenter clinical trials.
Consistently, different TLR9 agonists including IMO have been tested in multicenter phase I/II studies in patients with advanced RCC (Kuzel et al, 2009; Thompson et al, 2009).
Our conclusion should be tested in future multicenter, prospective, longitudinal studies.
LOGIC-Insulin still has to be tested in a large, practical multicenter clinical trial in which the centers' level of expertise in TGC will be less.
The potential benefit from antithrombin treatment of women with HELLP syndrome might be a reasonable objective to be tested in future well designed multicenter studies.
The early goal-directed sedation concept will now be tested in an adequately powered, multinational multicenter randomized trial with a patient-centered outcome [ 42].
And furthermore, the top associated SNPs were tested in a multicenter case-control population [31].
Advanced imaging methods such as delayed enhancement magnetic resonance imaging of the left atrium are currently being developed but are cumbersome and have not yet been tested in large multicenter clinical trials [4 7].
A combination of IL-10 and methotrexate was tested in a multicenter, placebo-controlled, dose-escalating study.
rFVIIa has indeed been tested in a multicenter multinational randomized controlled trial [ 7] and was shown to decrease hematoma enlargement, disability, and 90-day mortality.
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