While some proteases show a high degree of selectivity for a given sequence (i.e. caspases which require a P1 aspartic acid) and can be targeted with relatively selective substrates, others show high promiscuity and are able to cleave a wide variety of peptide sequences.
Overall, the results demonstrate that the active site of this protein kinase can be targeted to generate an isoform selective inhibitor with in vivo CNS efficacy.
This imbalance could be targeted by either pharmacological antagonism to CRF receptors or, in the future, with novel selective techniques of brain stimulation.
With their dedicated Facebook pages and selective advertising, companies have been targeting interest, tracking clicks, and building customer acquisition databases.
We envision that this HSNs encapsulating active enzymes can be conjugated with selective probes and targeting ligands to detect ROS in specific organelles or cell types of interest.
Spectral crowding for larger protein targets (>30 kDa) can be resolved with selective labeling of amino acids.
I further show that model predictions about inter-module communication during the processes of stimulus identification and target consolidation are associated with selective increases in coherence at the predicted points in time.
Clinically, inhibition of the estrogen signaling pathway is achieved mainly by targeting ER with selective ER modulators (SERMs) or the pure antiestrogen Fulvestrant, and blocking estrogen synthesis through aromatase inhibition [3], [4].
Enemy targets with selective eyesight are the norm in Project IGI: I'm Going In, by Eidos Interactive.
Further studies of anti-FXa antibodies in APS, SLE and other non-autoimmune thrombotic disease cohorts are now required to evaluate whether targeting FXa with selective inhibitors in patients bearing anti-FXa antibodies may be an effective treatment strategy.
