Sentence examples for be targeted to modulate from inspiring English sources

Therefore, miRNAs can be targeted to modulate the invasion-metastasis cascade (Lin et al., 2015).

Therefore, the importance of characterizing the monocyte/macrophage populations involved employing multiple methodologies and functional characteristics cannot be underestimated, particularly for the indentification of specific populations to be targeted to modulate the fibrotic process.

Together, these results indicate that the PPAR network may play a role in radiation-induced biological response and that it may be targeted to modulate radiation damage in various tissues.

Our work raises the possibility that ICAM-3 may be targeted to modulate macrophage/monocyte recruitment to sites where leukocyte cell death may be occurring.

Future studies will reveal whether these alterations pinpoint to converging pathways that could be targeted to modulate or monitor the pathogenesis of genetically different cerebellar diseases.

Specifically, the mechanisms for repairing topoisomerase-associated DNA breaks that accumulate following treatment with Top I poisons, such as irinotecan, comprise proteins that can be targeted to modulate sensitivity to these agents.

Thus both are targeted to modulate the EGFR quaternary structure equilibrium, but with different stabilization targets, allowing a combination therapy to target multiple EGFR structural isoforms to limit the quaternary structure dynamics essential for EGFR function.

From a therapeutic point of view, interventions ameliorating aging/neurodegeneration-related pathologies have therefore been targeted to modulating anti-oxidant mechanisms as well as inflammatory processes, DNA repair mechanisms and modulation of neurotrophic receptor systems [25] [28].

The development of a biologic should arise out of a knowledge of the pathogenesis of the inflammatory disease, and be targeted to inhibit or modulate specific components.

Where some splice mutations result in non-functional or deleterious protein isoforms, AOs could be targeted to mutated splice motifs, thereby modulating the splicing process and restoring the expression of functional protein.

These findings suggest that impaired immune signalling in response to NOD1/2 stimulation is a general defect in XLP2 and demonstrate that the XIAP BIR2-RIPK2 interaction may be targeted pharmacologically to modulate inflammatory signalling.