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Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects.
Both peripheral and central nerve terminals at the spinal cord can be targeted to induce pain relief by TRPV1 agonists.
We conclude that other pre-erythrocytic parasite antigens, possibly hitherto uncharacterised, can be targeted to induce sterile immunity against malaria.
This study together with ours [22], provide evidence for the presence of hitherto uncharacterized antigens that can be targeted to induce sterile immunity against malaria.
Third, such genes may be targeted to induce male sterility in an improved sterile insect technique [ 16].
This model can be used to further elucidate pathways that could be targeted to induce neural repair in humans affected by TBI.
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Importantly, using this approach, epigenetic effector domains can be targeted to the gene of interest to induce mitotically stable gene expression modulation (De Groote et al, 2012).
PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage.
Statins should, theoretically, prevent AA-induced mesenchymal to amoeboid switching by inhibiting the post-translational modification of the Rho GTPases by GGPP, thereby preventing Rho being targeted to the membrane to induce its signalling cascade.
Most importantly, SOCS6 is targeted to mitochondria and induces mitochondrial fragmentation mediated through an increase in DRP1 fission activity.
Importantly, we showed that phage particles displaying single-chain variable fragment (scFv) of an anti-DEC-205 monoclonal antibody were targeted to DCs and were able to induce maturation, even in the absence of maturation stimuli (Sartorius et al, 2011).
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