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This suggests that MLV PICs may be targeted to differentially used promoters and enhancers, engaged by the Pol II transcriptional machinery in a cell-specific fashion.
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Genes differentially expressed between BRCA1 and sporadic basal cancers were cross-matched with list of genes predicted to be targeted by differentially expressed miRNAs, to obtain a list of genes predicted to be regulated by RISC mediated cleavage (Additional file 1: Table S6).
The findings also point to the need for mothers (with low education), boys, and children from lower SES to be targeted (albeit differentially at different stages) as intervention points for adolescent alcohol prevention initiatives.
We therefore asked whether up-regulated PSP genes were predicted to be targeted by differentially expressed miRNAs.
STRING (v9.1) [ 32, 33] was utilized to determine any known and putative interactions among the differentially expressed genes that were also estimated to be targeted by the differentially expressed microRNAs.
Endogenous ABCG2 is overexpressed in MCF-7/MR cells and is targeted differentially to the membrane of EVs [8].
These results demonstrate that the ABDs of spectrin superfamily members caused distinct effects on actin filaments and were targeted differentially to dendritic spines.
DIANA-miRPath v2.0 pathway enrichment analysis (Papadopoulos et al, 2009) was used to detect molecular pathways that are targeted by the miRNAs differentially expressed between fMBC and fFBC.
Given its mechanism of action, we wondered whether Drp1 could be differentially targeted to mitochondria of LINCL cells, even if the total abundance of this protein is unchanged in these cells.
Resources should be differentially targeted to this area given its larger malaria burden.
To detect pathways that were targeted by small molecules, disease-related differentially expressed genes are first enriched into pathways.
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