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NF-κB may be targeted through the glutamate receptors, calcium influx and oxidative processes [15], [16], [25] [28], all affected by cycles of alcohol consumption and withdrawal.
Overall, our data demonstrate that the formation of dimeric and oligomeric aSyn species, both of which are thought to precede the formation of larger intracellular inclusions, are central steps towards cytotoxicity which can be targeted through the activity of molecular chaperones, such as Hsp70.
Conversely, prostate cancer patients without the TMPRSS2 ERG fusion gene may be better suited for therapies that target IGFs and Jak-Stat signalling, in which IGF signalling can be targeted through the use of tyrosine kinase inhibitors or monoclonal antibodies.
Sumoylation can be targeted through the use of anti-SUMO antibodies or hexahistidine-tagged or signature-tagged SUMO [ 85] in immunoprecipitation experiments coupled with MS [ 74] or western blotting of target proteins [ 86].
In that study, the treatments effect of a combined cognitive behavioral therapy and bright light therapy showed a large reduction of depression symptoms, suggesting that both the sleep problems and the co-occurring depressive symptoms may be targeted through the same interventions [ 34].
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A retrospective study of the association of air pollution exposure and birth weight in Accra through the use of hospital administrative records is feasible provided mothers are targeted through the public health units, which is responsible for child immunization.
Among blogs that were targeted through the DMCA, 43% of the blogs were still there, the blog was suspended in 32% in the cases, 13% of the blogs were deleted or relocated by the user.
The American public -- that massive segment of it that was targeted through the mainstream media to donate to Haiti -- knows very little about most countries, including its own.
For many people, especially members of minority groups who have been targeted through the use of marijuana laws, this break in the dam of marijuana prohibition is a cause for celebration.
Vaccine-preventable diseases have been targeted through the national EPI initiative.
Such a model raises the question of how RuBisCO complexes are targeted through the starch sheath during pyrenoid growth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com