Sentence examples for be targeted simultaneously to from inspiring English sources
Further, the available information may help to predict combinations of genes that need to be targeted simultaneously to impact orofacial development due to redundancy.
This lack of good cytotoxic activity after either MEK or PI3K inhibition alone suggests that multiple signalling pathways need to be targeted simultaneously to induce melanoma regression.
Such proteins can be targeted simultaneously to achieve excellent antibacterial effect, although individually either one of them would not be good targets.
Other lectin chromatography approaches, such as serial lectin affinity chromatography (SLAC), have relied on multiple lectins so that different subsets of glycoproteins can be targeted simultaneously to compare and detect changes in glycosylation patterns or to elucidate structural differences between glycoforms.
Increasing numbers of studies demonstrate that some proteins are targeted simultaneously to more than one compartment by a range of mechanisms, involving composite targeting sequences and/or transcriptional and translational controls.
However, single therapies often allow resistance to develop in tumor cells, suggesting that several pathways will need to be targeted simultaneously if we are to eradicate GBM in patients.
Each of the Septin-9 proteins will need to be targeted simultaneously with highly specific monoclonal antibodies to determine whether the observed aberrant methylation in one CpG island leads to a reduction in protein expression, and if all isoforms are affected equally.
Collaboration is also necessary among specific CCA and DRR organizations if common goals are to be targeted simultaneously (Birkmann and von Teichman 2010).
Clearly, large phase III trials cannot be used when dozens of deregulated signaling pathways are to be targeted simultaneously.
From the available information, it appears that several epitopes need to be targeted simultaneously for an effective therapy through the use of a polyvalent vaccine.
Furthermore, it is a burning question whether new bone formation can be prevented if inflammation is suppressed early enough or whether both inflammation and new bone formation have to be targeted simultaneously.
