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Primary and secondary KIT mutations could be targeted simultaneously by a combination of tyrosine kinase inhibitors.
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Increasing numbers of studies demonstrate that some proteins are targeted simultaneously to more than one compartment by a range of mechanisms, involving composite targeting sequences and/or transcriptional and translational controls.
A review concluded that antibiotic use was reduced by such campaigns, at least when the public and the physicians were targeted simultaneously [ 42].
Each miRNA has the potential to regulate multiple different mRNA targets simultaneously, while a given mRNA target might similarly be targeted by multiple miRNAs (reviewed by [ 13]).
A single miRNA can target hundreds of mRNA transcripts, and a single mRNA transcript simultaneously can be targeted by more than one miRNA, ensuring fine-tuned and/or redundant control over a large number of biological functions.
Therefore, it is highly desirable to create a means by which cancer cells could be targeted with high specificity and be simultaneously imaged in vivo [4].
"We were targeted by animals.
It was alleged they were targeted by the authorities in a crackdown on drug dealing in the Little London area of the city, which led to the largest number of Asbos simultaneously issued in the UK.
Sportsmen are being targeted by mass murderers.
They have long been targeted by militants.
It has been reported that when a miRNA has multiple binding sites in the 3'-UTR of its target gene, the binding sites could be simultaneously targeted by the miRNA [27], [28].
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