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If confirmed in further research, particularly in a prospective study with sufficient incidence of T2D and CVD over time, the findings in these two studies suggest that the APOE rs439401 TT-genotype might be used to identify persons at high risk of developing T2D and/or CVD who might be targeted for preventive interventions.
Furthermore, these age groups should be targeted for preventive public health interventions.
People with chronic medical conditions that are traditionally associated with a higher risk of severe complications following seasonal influenza virus infection should be targeted for preventive interventions and for early treatment with antiviral drugs should they develop a respiratory illness.
A few sentinel sites may appropriately represent the situation in-country and to inform public health officials on groups that need to be targeted for preventive and treatment measures.
Although these adults would not satisfy the new A1C recommendation for the diagnosis of diabetes, they would be targeted for preventive therapy to reduce diabetes risk, which may also prompt a fasting glucose measurement.
Although alcohol use is comparatively low in populations of African descent, large proportions of African Caribbean and Sub-Saharan African men still consume more than the government recommended daily drinking amounts and therefore need to be targeted for preventive care and advice on alcohol moderation [ 126].
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It is generally assumed that the three burnout dimensions do not develop simultaneously, and hence, knowledge about the causal order of the three burnout dimensions can be relevant for the early recognition of burnout and the identification of "high-risk" people who could be targeted for early, preventive interventions [ 6, 7].
The International Expert Committee [ 19] and the American Diabetes Association [ 20] suggest that individuals with an HbA1c between 42 and 48 mmol/mol (6.0% and 6.5%) might represent a group in which the risk of development of diabetes is very high and which could therefore be targeted for individual preventive interventions.
An important question to be answered is whether the microenvironment can be targeted for therapeutic or preventive strategies.
Clinical leaders, risk managers, liability insurers and regulators all lack reliable methods for systematically determining which doctors should be targeted for assistance and preventive action before they acquire troubling track records.
This study will provide a wealth of epidemiological and biomarker data that should be invaluable in the identification of potentially modifiable, causal risk factors for diabetes-related cognitive impairment, liver dysfunction and vascular disease, which can be targeted for the development of preventive and therapeutic interventions.
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