Although Ali had already been declared ineligible for military service, the Army changed its eligibility standards, and suddenly Ali was targeted for induction.
To ascertain which of the Akap12 isoforms is targeted for induction with retinoids, exon-specific probes to each Akap12 isoform were designed and applied to samples of RNA from atRA-stimulated PAC1 SMC.
We have identified at least five cancer-relevant activities of CD95 that could be targeted for cancer therapy, and one (apoptosis induction through CD95) that should not be.
The exact location and properties of undifferentiated, progenitor cells that give rise to luminal and myoepithelial cells in the adult breast is not well defined [ 4, 10, 11], and hence the hierarchical relationships between progenitor populations that may be targets for cancer induction are still speculative.
The SCGE assay with rodent cells has the advantage that HA-induced DNA damage can be monitored in a variety of organs which are targets for tumor induction by HAs.
As CLU overexpression mitigated, whereas CLU knockdown exacerbated NP-induced apoptosis, we postulated that CLU is targeted by NP for cell death induction.
Interestingly, several protein tyrosine phosphatases that can deactivate STAT3 signaling through direct dephosphorylation of p-STAT3 (Tyr 705) might be useful targets for induction of cancer cell death.
To further demonstrate that antisense nc-rRNAs are potential targets for induction of apoptosis, additional complementary LNAs listed in Supplementary Figure S1a were tested.
Sphingomyelin phosphodiesterase, phospholipase A2 and lysosomal phospholipase A1 are shown to be likely targets for the induction of phospholipidosis by inhibition of phospholipase activity, while lanosterol synthase is predicted to be associated with phospholipidosis being induced by enhanced cholesterol biosynthesis.
Here, we present our rationale suggesting why such potent early CTL responses that exert an antiviral effect may be particularly attractive targets for induction by candidate vaccines.
