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However, TGCTs harbour epigenetic alterations, which can be targeted by specific therapeutic approaches.
In this way, HSPs may have important therapeutic implications and they can be targeted by specific drugs.
Similarly, blood flow can be altered with antiangiogenesis drugs and tumor cells in acidic regions can be targeted by specific metabolic inhibitors and buffer therapies.
In conclusion, this study deciphering the physical and functional interactions of the Hsp70-StiA-Hsp90 Hsp70-StiA-Hsp90 Hsp70-StiA-Hsp90o the mecomplexs of tolerance to casprovided inew. fuminsightsnd revealed a key C-terminto mothe of Hsp70, which can be targeted by specific inhibitors, such as pifithrin-μ, to enhance the antifungal activity of caspofungin against A. fumechanisms
Several, including CL, PE, PI, and gangliosides, are targets of autoantibodies in human autoimmune diseases, and cell surface gangliosides on neoplastic cells can also be targeted by specific antibodies.
Alternatively these SLS may be targeted by specific nucleases and rapidly degraded, thus functioning as RNA instability determinants.
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Our meta-analysis suggests that while some local, direct drivers and a few regional indirect drivers of deforestation and forest degradation are being targeted by specific REDD+ interventions and associated benefit-sharing mechanisms at the project-level, most national and international indirect drivers are not.
Similarly, already deposited ECM proteins are targeted by specific enzymes, metalloproteinases, that are responsible for the continuous remodeling of ECM and allow cell movement and size adaptation.
Consequently, inadequate taxonomic resolution limits options for early detection and rapid response and for various subsequent management options when the wrong species is targeted by specific control measures.
Analyses of mRNAs that are targeted by specific RNA binding proteins have similarly shown that often, the proteins encoded by the target mRNAs are functionally related [ 67, 68, 73].
As alluded to above, utilization of different scaffolds could allow for localized signaling, by virtue of being targeted by specific kinases, or could control the selectivity of Crk signaling.
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