Sentence examples for be targeted by small from inspiring English sources

Processing and gating defects can be targeted by small molecules called generically correctors and potentiators, respectively.

"Even if it isn't," he adds, "it could still be targeted by small molecules or other drugs".

This chapter discusses how various cellular processes regulating the oncogenesis can be targeted by small molecule inhibitors.

Recent structural and functional studies of the HIV-1 surface envelope glycoprotein gp120 have revealed sites of vulnerability that can be targeted by small molecule and peptide inhibitors, thereby inhibiting HIV-1 infection.

Naturally, 18F would not be the best choice for all targeting agents, but there are several receptors for peptides, such as integrins, somatostatin, bombesin/gastrin-releasing peptide, etc., that could be targeted by small peptides, where a radionuclide with a 2-h half-life, such as 18F, would be ideal [2].

The fact that some receptors are overexpressed in several tumor types and can be targeted by small peptides, proteins or antibodies conjugated to radionuclides has been used in the past for the development of peptide endoradiotherapeutic agents such as 90Y-DOTATOC or radioimmunotherapy of lymphomas with Zevalin.

The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers.

We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response, and immunoglobulin-based therapeutics.

The structural diversity afforded by the α-methylene-β-lactone scaffold thus expands the landscape of serine hydrolases that can be targeted by small-molecule inhibitors and should further the functional characterization of enzymes from this class through the optimization of target-selective probes.

From the KChannelDB (http://www.receptors.org/KCN/), we extracted 111 KIC genes, 14 of which were targeted by small molecule drugs according to DrugBank.

Also, steroid sulfotransferases are targeted by small RNAs in fiber initials [ 59].