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Moreover, whether there are hot-spots on PD-1 or PD-L1 to be targeted by different therapeutic antibodies requires further investigation.
These powerful genomic approaches are recommended by opinion leaders to identify specific pathways that could be targeted by different drugs depending on patients' subset [3].
Such mouse models are available for most organs that may be targeted by different gene therapy methods.
Different individual features of a tumour may be targeted by different drugs.
Proteins may contain multiple phosphorylation sites, which may be targeted by different kinases/phosphatases [ 2].
Thus, in different datasets, the same pathway may be targeted by different molecules.
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We also observed that the CCAAT binding transcription factor At1g54160 is targeted by different mature miRNAs (1, 4, and 5).
Notably, the same residues or same regions are targeted by different E3 ligases or different signaling.
One example is the soybean lectin gene (Le1 ), where distinct regions are targeted by different soybean-specific methods.
The inhibition of this enzyme, which is targeted by different medicines, guarantees a protective function against dementia [ 3].
Wang et al. [ 61] discovered that cytochrome P450 was targeted by cotton-specific miRNA, miR2948-5p, indicathat thet the Cytochrome P450 families were targeted by different miRNAs in cotton.
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