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Once identified, these leads could then be systematically improved to high affinity by utilizing thermodynamic additivity of sequence variations.
However, some serious limitations including inherent toxicity, poor biocompatibility, and lack of multiplexed imaging and analytical systems should be systematically improved to further promote their use in cancer studies.
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Therefore, instead of an iterative key estimation technique based on successive refinement, the only way to obtain the correct key would involve a rather costly random search through a significant share of the keyspace until a configuration with small Hamming distance is found which can be systematically improved.
Acetaldehyde production was systematically improved by knocking out the competing metabolic pathways.
The elastic modulus and heat deflection temperature are systematically improved upon increasing the concentration of clay particles.
While the stability of PS films is systematically improved upon addition of the highly substituted copolymers, using the copolymer with relatively low ratio of ClMS group could lead to the opposite result.
The model was systematically improved using iterative cycles of manual rebuilding with the program Coot [77] and refinement with Refmac5 of CCP4 6.1.2 Program Suite [74], [75].
By bringing together muscle and ontology experts, the GO structure was systematically improved in five areas: muscle contraction, plasticity, development and regeneration; and for cell regions in the sarcomere and membrane-delimited compartments.
Our results indicate that environmental education needs to be improved in most of the institutions of higher education in China, and it should be systematically assessed and improved to meet the nation's rising demands in sustainable development, nature and resource conservation.
We hypothesized that undifferentiated hPSC growth rate, hEB formation, media formulation, and exposure to growth factors during cardiac differentiation could all be systematically optimized to improve cardiac differentiation.
To date, there are no universal solutions however best practices indicate strategies can be systematically used to improve health literacy for priority populations within specific contexts of care.
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