Only the implantation of BCNU polymers at the time of reoperation is supported by randomized trial data, having been shown to be superior to re-resection alone [ 11].
Even though several conservative treatments, such as eccentric training and ESWT, have been proposed for tendinopathy, very few of them are supported by randomized controlled trials [ 46].
However, recent years showed progress in the development of treatment options [ 8- 14] that are supported by randomized controlled trials [ 1, 7, 15- 19].
Lumpectomy followed by radiation therapy (RT) is the most common treatment for DCIS, the efficacy of which is supported by randomized trials and meta-analysis demonstrating a reduction in the risk for local recurrence by approximately 50% [ 2, 3].
The effectiveness of PARs has been questioned by some researchers [ 4, 10, 11], although the efficacy has been supported by randomized controlled trials presented in a number of reviews in recent years [ 6, 7, 12, 13].
This hypothesis is supported by randomized trials of pharmacologic therapies for PMS, as reviewed by Halbreich et al.[ 35], which demonstrate substantial variation in treatment response between symptom profiles.
Furthermore, these findings are supported by randomized evidence from the NPC trial and SELECT indicating that selenium supplementation may increase the risk of diabetes in selenium-replete populations such as that of the United States.
This is supported by randomized controlled trials where ACE inhibition has increased 6-min walking distance in elderly subjects and angiotensin II receptor blockade has shown a trend toward an improvement in quadriceps strength in subjects with COPD.
This theory is supported by randomized clinical trials that have shown beneficial clinical effects of the blockade of production of angiotensin-II (AII) by angiotensin converting enzyme inhibitor (ACE-I) medications or antagonism of AII action through angiotensin receptor blockade (ARBs).
Furthermore, even though common sense implies that less bone disruption increases spinal stability, data on TLA and cTLA approaches still need to be supported by a large prospective randomized trial to assess the preservation of spinal stability and patient outcomes compared to conventional approaches.
