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This system may be suitable to validate or even partially replace complex animal studies and, in particular, address the importance of isolated, specific synovial cell types in an experimental setting which reflects prominent features of joint destruction in RA.
Interestingly, looking at studies using TMAs vs studies using whole tissue sections (Table 3), both groups had similar ranges of FGFR1-amplified tumours (TMA: 6.5%–22% vs whole tissue section: 8.7%–17.3%) indicating that TMAs can be suitable to validate FGFR1 gene status on large patient samples.
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Classical model validation methods (e.g. k-fold cross-validation or Receiving Operator Characteristic (ROC) curves) are suitable to validate probabilistic but not discrete results [ 17], which are represented by a single point in the ROC space.
Thus, this operating condition is suitable to validate if the friction losses are determined correctly by the numerical model.
This approach is suitable to validate concepts derived from proteogenomics as well as effects of pharmacological treatments.
In [15], the eigenvector method is validated to be suitable to correcting phase errors for SA-ISAR data.
The BMQ-D has been validated and proved to be suitable to measure patients' beliefs in medicine in German primary care settings [ 26].
The PRNT50 was then validated and demonstrated to be suitable to detect and measure dengue serotype-specific neutralizing antibodies in human serum samples with acceptable intra-assay and inter-assay precision, accuracy/dilutability, specificity, and with a lower limit of quantitation of 10.
Validated and user friendly questionnaires, used in a telephone follow-up, could be suitable to identify patients in need of more attention.
Common economic gauges such as Return on Investment, Payback Period, Cost Benefit Analysis, Life Cycle Assessment and Life Cycle Cost are not suitable to validate OE options in households.
So, there might be more objective measures, which are more suitable to validate our tool (e. g. data derived from medication event monitoring systems or laboratory data).
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CEO of Professional Science Editing for Scientists @ prosciediting.com