We demonstrated that adding a second mutation (through genetic deletion of PTEN) to these lesions was sufficient to progress it to frank carcinoma.
Only one correct or incorrect response on a 'different' trial was sufficient to progress up to the harder level or return back down to the easier level respectively.
It is important to note, that just a small number of 4T1 metastatic cells (around 10 20, Fig. 1b) are sufficient to progress to a severe lung metastatic disease in the absence of primary tumors, indicating that these tumor cells may be particularly resistant or indifferent to the host immune system in order to persist.
Therefore, the residual PKB activity present in PKBα−/− thymocytes might be sufficient to permit thymocytes to progress to mature T cells despite accumulation of early thymocyte subsets at the DN to DP transition.
The UNFCCC process alone will likely not be sufficient to achieve swift progress on the long list of unresolved, highly controversial negotiation issues.
"Private investment is essential to foster the Venezuelan economy," he said, "but we do not think that private investment will, on its own, be sufficient to make people progress".
Plxdc2 alone may not be sufficient to enable these cells to progress along the differentiation pathway, which may require further molecular events absent in our culture conditions.
Should images of water pouring into the subway tunnels that occupied our newspapers a few weeks back be sufficient to stay us from progress?
It is shown that inclusion of a larger number of species in calculating cO (18 versus 7) makes little difference, such that the seven major species accessible to Raman/Rayleigh laser diagnostics are sufficient to quantify reaction progress in partially-premixed methane flames at atmospheric pressure.
"Whether the progress is sufficient to come to a decision by the deadline, I don't know".
