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For example, if there were four such genes each responsible for one-quarter of the families, a series of around 400 families with three affected sisters should be sufficient to map them, given a sufficiently dense marker map.
The study sample size will thus be sufficient to map rare variants without blowing the bank.
Our results also indicate that a modest selection of transcription factors may be sufficient to map most regulatory elements in the human genome.
Thus, despite the large number of existing human transcription factors, the results derived from the coverage analysis indicate that a relatively modest number of factors may be sufficient to map regulatory elements in a specific cell line.
For the nested qualitative study, we will collect data from 30 patients, a sample size that is likely to be sufficient to map the diversity of patients in primary care [ 29].
This might be thought to be sufficient to map uniquely to the transcriptome [ 11], but because transcript sequences are non-random, such tags are often too short to distinguish similar sequences.
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Entire vent colonies can potentially be mapped in a short time [18], and the resolution it achieves is sufficient to map deposits protruding by as little as a few centimetres from their surroundings.
The iPCR method is sufficient to map the insertion site for most transposable elements, and has been used in high-throughput screens to isolate the insertion sites for thousands of P-element and piggyBac transposable elements (e.g. Ref. [7]).
As the number of ETS regulated proteins identified in MudPIT was sufficient to map the ETS over-expression concept, lack of similar proportion of this class of proteins in iTRAQ platform possibly resulted in the disappearance of the same concept in the combined analysis.
Previous genetic maps [ 3, 4] were sufficient to map QTL to broad regions.
With reference genomes available, short sequence reads are sufficient to map their locations (except for repeated regions), and once mapped, millions of sequence hits are simply counted to determine their genomic distribution.
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