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The interaction of siramesine with mitochondrial membranes seems to be sufficient to functionally disable mitochondria and affect cell homeostasis in the long run, thereby initiating cell death.
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Whilst the rescue of the pump duration and R/E-spike ratio suggests the exogenous expression of slo-1a in the pharyngeal muscle is sufficient to functionally restore the normal behavior of the muscle.
This may be sufficient to reach most of the functionally relevant cortical layers of the mouse brain [ 5], but an assessment of the degree of out of plane signals will be necessary, as the sectioning ability may become coarser with deeper (z>400 µm) measurements in vivo.
However, miR-134 alone appears to be sufficient to fine-tune Pum2 levels within a functionally critical window.
Therefore, while certain genes necessary for nasal colonization have been functionally characterized, they may not be sufficient to establish carriage by themselves.
It is likely that no single TF will be sufficient to fully restore neuron-intrinsic growth potential, and that multiple, functionally interacting factors will be needed.
One reason for this could be that other CRT family members are functionally redundant with AtCRT1a, i.e. in the absence of AtCRT1a the other CRTs may be sufficient to maintain CRT activity.
"That should be sufficient to exonerate me".
This should be sufficient to stop blisters.
One vehicle should be sufficient to start.
Indeed, these neurons are sufficient to form a functionally connected circuit that extends from the JO to the VNS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com