Therefore, a short and/or a one-time treatment of cells with H2O2 or other oxidants may be insufficient to generate an oxidized form of wt Ras (e.g., wt Ras-SNO) but may be sufficient to activate wt Ras via the redox-mediated wt Ras activation mechanism.
These results suggest that ST interaction with PP2A is crucial to apoptin activation, and that inactivation of PP2A by ST might be sufficient to activate apoptin.
Finally, the addition of free polyubiquitin chains was shown to be sufficient to activate purified IKK1 and -2 in an in vitro reconstitution of IKK activation, suggesting that activation of these kinase subunits may result from trans autophosphorylation.
But they do bounce around them, and the wake-up system's sensitivity means even the smallest fragment of an ultrasonic signal will be sufficient to activate it.
In order to elicit a stretch reflex the force of the pull and subsequent strech velocity of the tibial translation must be sufficient to activate the proprioceptors.
However, the lateral growth of the thermally-grown oxide (TGO) and the thermal expansion misfit between TGO and the underlying bond coat (BC) induce internal stresses which can be sufficient to activate plastic deformation or buckling in the TGO.
Therefore, the DMSA-Fe2O3 caused differential effects on the expression of pro- and anti-apoptosis genes of HAECs; this may explain why the viability of HAECs was not changed at this low concentration of DMSA-Fe2O3, which might not be sufficient to activate the cell apoptosis pathway.
Thus, the injection of ES cells alone might not be sufficient to activate the NK cells in mice.
