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Under these conditions, the reversal of Plk1 addiction may be sufficient for triggering cancer cell-selective mitotic block and apoptotic cell death (Luo et al. 2009b), as has been demonstrated by the reversal of oncogene addictions (McMurray et al. 2008).
The stimulus s from Equation 12 uses a sine signal as a basis for stimulating both the noise reduction subsystem as well as the transient noise reduction subsystem: while a steady-state presentation of the sine signal would be sufficient for triggering the noise reduction, the dramatic change of the sine amplitude at time T1 is required to trigger the transient noise reduction.
Activation of the full cascade of KEs is considered to be sufficient for triggering the AO.
One can speculate that only partial or distant similarities between fibrillar rPrP and PrPSc structures may be sufficient for triggering conversion of PrPC into PrPSc by fibrillar rPrP.
A large dendritic depolarization occurred only rarely in unconnected cells (in <3% of the cells), when the background input itself happened to be sufficient for triggering BAC firing (Fig. 3 E, dashed black curve).
However, ectopic expression of a DMPK 3′UTR with as few as 57 CTGs in C2C12 mouse myoblasts was reported to be sufficient for triggering nuclear retention by means of foci formation (3).
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A one-hour pulse of Axitinib is sufficient for triggering cell senescence.
Both G C and A∶T mutations were detected, suggesting that the lesion introduced by AID is sufficient for triggering both types of mutations.
We are dealing here with a threshold corresponding to the amount of nociceptive information that is sufficient for triggering the reaction.
If PI3K is sufficient for triggering polarization and if Rac and PI3K proteins are both part of the same positive feedback loop, then uniform activation of native Rac should be equally effective in triggering polarization and migration (see scheme in Fig. 1C, right).
Interestingly, insulin exposure, as short as 4 h, was sufficient for triggering the lipid accumulation, whereas much longer treatment with HRG was required for achieving similar cellular response.
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