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Systemic drug administration would be sufficient for targeting in such a case.
This compact NOS was shown to be sufficient for targeting a reporter protein to the nucleolus.
Because total p27 levels are not affected, phosphorylation in T187 may not be sufficient for targeting p27 to protein degradation.
Nonetheless, these findings provide a proof-of-concept that sequencing of a limited number individual metastases may be sufficient for targeting of melanoma driver mutations.
Interestingly, these data also revealed that all of 10 tumours express miR-574-5p miR-574-5p miR-574-5psues preferentiandy expresincerS1-2, which is a tumour for miR574-5p, tissuesrexpreferentiallyR-574-5p might not bexpressd, and its steady state expression should be sufficient for targeting CerS1-2 in tumour tissues.
Therefore, the NLS sequence of the large simian virus (SV) 40 T-antigen (PPKKKRKV) known to be sufficient for targeting several proteins to the nucleus of mammalian and plant cells was fused N-terminally to the coding sequence of mRFP (monomeric RFP) and placed under the control of an estradiol-inducible promoter in the pER10 vector system.
Similar(54)
According to tests thus far, their implants can be powered beyond 12 centimeters below the skin, or a bit under 5 inches – which is sufficient for targeting most any vital organ in the body.
Our results suggest that the well-characterized AAV5 vector is sufficient for targeting therapy to photoreceptor cells.
As controls, neither GFP-CAT, the amino-terminal one-third of ARFGAP1 that has GAP catalytic activity on ARF1, nor GFP-GAP132, the middle third that is sufficient for targeting to Golgi [17], stimulated the formation of actin foci.
However, our immunocytochemistry data show that the chimeras were targeted to synapses, and previous results with different synaptotagmin-1/7 chimeras showed that including the N-terminal sequence of synaptotagmin-1 that contains an N-glycosylation site is sufficient for targeting to vesicles [48].
Thus, it is possible that ZNF644 or WIZ alone is sufficient for targeting G9a and GLP to certain loci for H3K9 methylation and transcription repression.
More suggestions(15)
be general for targeting
be sufficient for altering
be effective for targeting
be ideal for targeting
be necessary for targeting
be relevant for targeting
be sufficient for moving
be attractive for targeting
be sufficient for growing
be sufficient for leaching
be strategic for targeting
be sufficient for getting
be crucial for targeting
be responsible for targeting
be important for targeting
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