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The presence of the nick itself regardless of its terminal chemistry seems to be sufficient for optimal cleavage efficiency.
Incubation times of 12, 24, and 60 h at 37 °C were tested in order to evaluate the effectiveness of the enzymatic digestion; an incubation of 12 h proved to be sufficient for optimal results.
At this time, however, risk stratification based on clinicopathological data alone is unlikely to be sufficient for optimal treatment decision-making (Ficarra et al, 2005; Shariat et al, 2007; Canter et al, 2011).
Although the two readers that had no previous experience in CTC underwent a learning curve of 50 patients, some studies have shown that this may not be sufficient for optimal polyp detection [ 30, 31].
However, other rTMS studies have observed disrupted performance on cognitive tasks, including working memory, by means of rTMS application to the left DLPFC in isolation (e.g. Osaka et al. 2007), which indicates that compensatory mechanisms may not be sufficient for optimal task performance when a critical region is disrupted.
As there is increasing evidence showing that monotherapy with either IAP antagonists or TRAIL receptor agonists will likely not be sufficient for optimal antitumor activity in the majority of cancers, rational combination strategies will become particularly important to exploit the therapeutic potential of these compounds.
Similar(53)
The kinetics of 3D4 binding to LS9 closely paralleled the kinetics of binding to the entire rEBNA-1 protein indicating that this carboxyl region (aa 410 641) is sufficient for optimal recognition by 3D4.
The following four axioms are sufficient for optimal convergence.
The effectiveness of this layout was proven by excellent training and validation times, with few cycles being sufficient for optimal results.
The ratio CE/CV, thus, ranged from 0.005 to 0.25, indicating that the precision obtained with the sampling scheme was sufficient for optimal sampling [ 70].
Thus, it is possible that the basal level of IL-6 present in the host is sufficient for optimal T-cell proliferation or that IL-6 production by DCs is not necessary for maximal proliferation of CD8+ T cells.
More suggestions(15)
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