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Given the high concentration of potential Aβ plaques and associated binding sites in AD brain [34], this could also mean that a radioligand with a K d value of approximately 18 nM (BP (a combined measure of receptor density and affinity) = 1,432 nM/18 nM = 80) may be sufficient for imaging Aβ in AD.
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Fluorescence microscopy reveals that 0.5% label content is sufficient for imaging.
Early case studies found that the small positron yield (0.0032%) of 90Y was sufficient for imaging the microsphere distribution by PET [12 14].
Although there is a slight increase in this value compared with a freshly cleaved mica surface of ~0.05 nm, it is sufficient for imaging DNA and studying the interaction between protein and DNA.
This still yields a theoretic spot size of 5 µm, which is sufficient for imaging small retinal capillaries.
However, with a reasonably high numerical aperture, the sectioning is sufficient for imaging nuclear and cellular detail in human tissues such as, for example, the epidermis in skin and epithelium in ovaries [ 6, 7].
They are capable of producing high contrast per unit of particles, so that small quantities of SPION are sufficient for imaging therapy, thereby reducing the toxicity issues [ 49, 50].
The Z-axis actuator moves the focal volume over a range of ~400 μm below the tissue surface, which is sufficient for imaging colonic epithelium in the mouse (<200 μm) or human (<500 um).
This ROI was sufficient for imaging a large cross-section within the nucleus of single cells, and allowed acquisition rates as fast as 100 Hz (10 ms per frame).
Nevertheless, these data imply that though plaque dimensions will in general be sufficient for imaging-target visualisation, focussing on mere plaque size entails unsatisfactory prognostic information for clinical use.
Moreover, we believe that the sidelobe levels are sufficient for imaging of both targets of Figure 7. Figure 9 Reference image Iref of an isotropic point.
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