These are important experiments for the future, and we will extend this approach by co-targeting of a Mad1p scaffold, and test whether the concerted action of Mad1p and Bub1p is sufficient for generation of "wait anaphase" signals.
Although we have shown that the extracellular and transmembrane domains are sufficient for generation of microvilli, there are several possible mechanisms that could lead to this effect (figure 11A).
By contrast, Kras G12D activation was sufficient for generation of acinar-derived cysts; importantly, Ptf1a cKO; Kras G12D acini formed significantly larger cysts than those derived from Kras G12D pancreata.
In vivo, heregulin-induced HER3/HER2 transactivation, in the absence of HER2 over-expression, is sufficient for generation of adenocarcinomas while favouring the metastatic spread of breast cancer cells in mice [ 19].
That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has revolutionized the field and also highlighted the importance of OKSM as targets for genome editing.
Instead, the dictionary of fatty acid- and sphingoid chains and lipid classes may be sufficient for the generation and consideration of all lipid molecules.
The results support the view that synthetic heavy chain diversity alone may be sufficient for the generation of high-affinity antibodies from phage-displayed libraries; thus, it may be possible to dispense with the light chain altogether, as is the case in natural camelid immunoglobulins.
It should be emphasized that the available evidence [15], [16], [18], [51], [53], [54], together with the presents results, indicate that loss of apical-basal polarity (including loss of adherens junctions) is necessary, but may not be sufficient, for the generation of progenitors that divide, in an abventricular location, symmetrically into two neurons.
A certain level of Ca2+ increment may be sufficient for NADPH oxidase-mediated ROS generation.
Those estimates vary greatly: some model suggest 10 000 generations may be sufficient for the emergence of ecologically differentiated species under favourable conditions [ 5, 72], or possibly much faster [ 60, 73].
