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The rest period between trials was 30 s, which was considered to be sufficient for full recovery.
Animal model data suggest that constitutive activation of JAK-STAT signaling can drive abnormal hematopoiesis and may be sufficient for full development of the MPN phenotype.
Furthermore, it is expected that the presence of high-risk HPV would not be sufficient for full tumourigenic transformation and further changes would accumulate over time in a step-wise manner.
Furthermore, the growth debilitation and avirulence found with RCOL-1 are not likely to have resulted just from the altered ribosomal gene cassettes, since there are mostly pure copies of C. oryzae-sativae in RCOL-1, which should be sufficient for full function.
While activation of a single MEK isoform was shown to be sufficient for full neoplastic transformation of intestinal epithelial cells, we observed that MEK2DD-expressing cells display a slightly more transformed morphology and are more invasive than cells expressing MEK1DD in vitro.
Although we see activation of both MKK3 and MKK6 in the perfused rat heart, which should be sufficient for full activation of p38, we cannot rule out the possibility that an MKK-independent component, such as TAB1 or AMPK, may contribute to p38 activation during ischaemia.
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But it is unclear why Robert and Baylis think that someone's being confused about the specific case of the chimera would also make them revisit their general belief that being a human being is sufficient for full moral status.
All contribute to high-NaCl-induced activation of TonEBP/OREBP, but no individual one is sufficient for full activation [5].
Nevertheless, even in low doses of RANKL, only an additional 2 days were sufficient for full OC differentiation in NT3.catK cells.
A dark period of 24 h prior to electrophysiological recording was sufficient for full recovery of photocurrents, showing that the decrease in current amplitude was not permanent but slowly reverted in the dark within several hours (Fig. 1E).
Notably, heterozygous mice did not show any abnormalities in postnatal growth and survival as well as blood or bone parameters highlighting that only one Wwox allele is sufficient for full function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com