Therefore, while two genomes may be sufficient for detecting long conserved exons, three to fifteen genomes may be needed to detect TFBS.
In the present study, we demonstrated that the N-terminus of GCS1 by itself is sufficient for gamete fusion and a highly conserved region, such as the HAP2-GCS1 domais, is critical to successful fertilization in both plants and parasties.
Similarly, while the human-mouse-rat comparisons that has demonstrated that ~60% of cassette exons conserved in mouse and rat are not conserved in human and ~20% of cassette exons conserved in human and one rodent are not conserved in the other [ 9] are sufficient for the estimation of the loss rate of cassete exons; they do not allow one to estimate the rate of the cassette exon gain.
The divergence time between these groups is sufficient for non-functional sequences to have diverged while important genes are sufficiently conserved to enable their clear identification.
Transcriptome data is sufficient for enzyme discovery, only when information about the primary sequence, conserved residues, domains or motifs is available.
Remarkably, the transmembrane domains of Sec61β homologs are sufficient for heterologous complementation, demonstrating that the TMD region supports a fundamental biological function that is conserved across species.
Moreover, the observation that the HMG domain is sufficient for Sox2 self-association suggests that HMG domains of distinct Sox proteins, which are highly conserved, may be able to promote Sox protein association.
Recent studies have demonstrated that a conserved N-terminal 12 amino acid domain of SALL1 and FRIEND OF GATA1 (FOG-1) is sufficient for recruiting Mi-2/Nucleosome Remodeling and Deacetylase (NuRD) complex and mediating transcriptional repression [22] [24].
