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However, in subsequent analyses only few could be successfully validated as being predictive, clinically useful, or effective.
While the biological role of XT secretion is not understood, the quantification of XT activity in the peripheral blood and other body fluids could be successfully validated as a marker of the actual proteoglycan biosynthesis rate (2).
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Twelve out of the 16 DE genes and one coming from the non-DE group were successfully validated as DE; and two out of the four non-validated genes (PLA1A and CASP4) were close to statistical significance (Table 2).
A few FASII enzymes have already been successfully validated as antibacterial targets.
The Cumulated Ambulation Score has been successfully validated as a predictor of surgical outcome for hip fracture surgery.
The trained network is successfully validated, as it is proven capable to accurately predict crack positions and lengths of a lap-joint structure, which is damaged by fatigue cracks of unknown location and extent.
All ten SNVs were successfully validated as being somatic.
Secernin-1 has been successfully validated as a potential diagnostic biomarker candidate for prostate cancer in tissue using Western blot analysis.
Most importantly, this model was successfully validated, as it was able to recover altered configurations observed experimentally in the corresponding simulated mutants and yielded the same results in the continuous version.
Presently, the mouse embryonic stem cell test (EST) is the only system based on a mammalian cell line, which was successfully validated as an alternative for in vivo embryotoxicity testing (Genschow et al. 2002).
Hence, the coactivator binding site on nuclear receptors has been successfully validated as a bona fide pharmaceutical target in the last decade, and several corresponding drug discovery undertakings have been reported on the subject.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com