Sentence examples for be successfully targeted with from inspiring English sources
Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines.
It may be the case that crimes that cluster together in topical space may be successfully targeted with a common set of crime prevention measures.
Altogether, these proof-of-principle results confirm that the CRL substrate interface can be successfully targeted with small molecules.
In vivo studies with these two human breast cancer cell lines confirm that LHRH receptors on TNBC can be successfully targeted with the cytotoxic LHRH analog, AEZS 108.
Thus, we showed that tumoral LHRH-receptors in TNBC can be successfully targeted with AEZS-108, thus dramatically increasing the anti-tumor effect of doxorubicin.
Receptors for LHRH (luteinizing hormone-releasing hormone) can be successfully targeted with AEZS-108 [AN-152], an analog of LHRH conjugated to doxorubicin.
One such example, the group of compounds known as reactive oxygen and nitrogen species (RONS), has been successfully targeted, with a body of work devoted to antioxidants designed to prevent damage by soaking up the radical by-products of respiration.
In each case, one site overlapped a sequence that had been successfully targeted with ZFNs (ryT2 and yT2; Figure 1).
For example, the HIV-1 protease has been successfully targeted with a diverse set of clinically useful strand mimics.
It was directed to the same site in the yellow gene that was successfully targeted with ZFNs (Bibikova et al. 2002).
HER2/neu is an oncogene that facilitates neoplastic transformation due to its ability to transduce growth signals in a ligand-independent manner, is over-expressed in 20-30% of human breast cancers correlating with aggressive disease and has been successfully targeted with trastuzumab (Herceptin®).
