Sentence examples for be successfully targeted for from inspiring English sources
Numerous data has indicated that autophagy can be successfully targeted for the treatment of multiple cancers.
The data support UPR-mediated translational failure as a generic pathogenic mechanism in protein-misfolding disorders, including tauopathies, that can be successfully targeted for prevention of neurodegeneration.
Its oncogenic function, coupled to membrane expression, led to the definition of an oncoantigen [ 4, 5], that is, an oncogene which is also a tumor-associated antigen that can be successfully targeted for tumor prevention and therapy.
Proof of principle that the PI3K pathway can be successfully targeted for clinical use in cancer has been demonstrated by the development of rapamycin analogues (CCI-779, RAD-001) that inhibit the mTOR kinase and are now undergoing evaluation in phase II trials in CRPC.
While hyperphosphorylated tau is ubiquitinated in patients with AD [ 38, 44], indicating that pathological tau species may be successfully targeted for degradation, the accumulation of ubiquitinated tau species in those patients suggests dysfunction of either proteasomal or lysosomal degradation pathways contributes to NFT formation in disease.
We describe hot spots in the active sites of certain BVMOs that have been successfully targeted for changing the substrate scope, as well as the possibility to influence this property by allosteric effects.
Keratinocytes or dermal fibroblasts have been successfully targeted for various applications including the correction of genetic skin disorders, the treatment of systemic diseases or cancer and wound-healing enhancement.
The two defeated incumbents were successfully targeted for being in office during L.A. Unified's failed and costly effort to provide every student, teacher and campus administrator with an iPad.
Aberrant expression and activation of EGFR and ERBB2 (have) have been successfully targeted for cancer therapeutics.
As protein kinases have been successfully targeted for inhibition in cancer, this diverse protein superfamily warrants consideration as a target for parasitic diseases as well [ 2, 5].
Protein kinases are a diverse family of enzymes which have been successfully targeted for inhibition in human cancers, and show promise for treating infections by protozoan pathogens as well [ 27].
