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However, the interpretation of PET and SPECT images remains a challenge because the changes can be subtle in the early course of the disease and there can be some overlap with normal aging and other dementia types [31].
Changes in metabolic composition are likely to be subtle in the early stages of any disease.
The interference may be subtle in the reference interval but may increase steadily with increasing HbA1c.
Any potential dysmorphic or associated features should be noted and the experience of a clinical geneticist obtained early in such situations, as such signs can be subtle in the early newborn period.
Further, the effects of even modest IAH in critical illness may be subtle in the setting of multiple organ failure [ 46], and pressures as low as 10 mmHg may have significant end organ effects [ 47].
The loss may be subtle: in the TG2576 APP mouse line, no loss was initially observed, but rather an increase, correlated with a deficit in synaptic function [ 165]; a more exhaustive stereological and ultrastructural analysis in the same line found a decrease in the synaptic density of the external molecular layer of the dentate gyrus, in close relation to the Aβ deposits [ 87].
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The gradations are subtle in the women's game, too.
But one of the things that's subtle in the scene is the sound design.
Political ads have rarely been subtle in the past, but this current slew could insult the intelligence of a silverfish.
Their commercials, when at last they appeared, were subtle in the extreme, never mentioning the scandal overtly and airing only in districts that were full of angry Republicans.
GRAYZ The changes at Gray Kunz's restaurant are subtle in the dining rooms, more extensive in the kitchen, and large on the menu, which is now à la carte.
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